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David Dornan, PhD
January 1, 2020
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Aadi Bioscience Breakthrough Therapy nab-Sirolimus (ABI-009) Independent Reviewed Data Released from the AMPECT Registration Trial in Advanced PEComa
Mohammad Hirmand, MD
Study-end analysis from AMPECT, an open-label, phase 2 registration trial of patients with advanced malignant PEComatreated with
nab
-sirolimus, showing durability of response and long-term safety
nab
-Sirolimus improves mTOR pathway suppression and antitumor activity versus oral mTOR inhibitors in
PTEN
null bladder cancer (UMUC3) and
TSC2
null liver cancer (SNU398) xenografts
Mutational analysis and safety/efficacy in a phase 2 multi-center investigation of ABI-009 (
nab
-rapamycin) in patients with advanced malignant perivascular epithelioid cell tumors (PEComa)
Evaluation of nab-Sirolimus in Combination With PI3K Pathway Inhibitors to Overcome PI3K/mTOR A117Resistance in PI3K-Mutant Breast Cancer Cell Lines
Long-term follow-up for duration of response (DOR) after weekly
nab
-sirolimus (ABI-009) in patients with advanced malignant perivascular epitlhelioid cell tumors (PEComa): Results from a registrational open-label phase 2 trial, AMPECT
Biomarker Analysis From AMPECT Correlating Response to
nab
-Sirolimus in PEComa With
TSC1
and
TSC2
Inactivating Alterations
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