Aadi Bioscience’s lead investigational drug candidate product nab-sirolimus leverages albumin-bound nanoparticle technology that is based on similar technology as ABRAXANE^® (nab-paclitaxel; Abraxis Bioscience acquired by Celgene Corp in 2010)

Albumin is accumulated in tumor tissues, either due to the leaky capillary system and defective lymphatic drainage of tumors [1] or through an active gp60/caveolae-mediated transport process across tumor blood vessel endothelium [2, 3]. Importantly, albumin is taken up by proliferating tumor cells via endocytosis and macropinocytosis, then catabolized by lysosomal degradation to support de novo protein synthesis, energy, and tumor growth [4]. The accumulation of albumin in solid tumors provides potential rationale for albumin-based drug delivery systems to preferentially target tumors.

Preclinical Differentiation vs. Existing mTOR Inhibitors

In preclinical animal models, the nab technology investigational drug candidate nab-sirolimus has demonstrated advantages over existing mTOR inhibitors including: