The mTOR pathway plays a major role in multiple critical cellular processes. Aberrant mTOR pathway activation is associated with a broad range of diseases and frequently driven by alterations in mTOR or other mTOR pathway genes (e.g., TSC1 and TSC2 ). Inactivating alterations in TSC1 and TSC2 drive mTOR pathway activation and tumor growth TSC1 and TSC2 form a tumor suppressor … Continue reading mTOR Pathway